Structure of PDB 7brk Chain A

Receptor sequence
>7brkA (length=426) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SDLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRMVL
GSSENAAGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYSAAPVGRFTAHW
RVPLLTAGAPALGIGVKDEYALTTRTGPSHVKLGDFVTALHRRLGWEHQA
LVLYADRLGDDRPCFFIVEGLYMRVRERLNITVNHQEFVEGDPDHYPKLL
RAVRRKGRVIYICSSPDAFRNLMLLALNAGLTGEDYVFFHLDVFGQSLKS
AQGLVPQKPWERGDGQDRSARQAFQAAKIITYKEPDNPEYLEFLKQLKLL
ADKKFNFTVEDGLKNIIPASFHDGLLLYVQAVTETLAQGGTVTDGENITQ
RMWNRSFQGVTGYLKIDRNGDRDTDFSLWDMDPETGAFRVVLNYNGTSQE
LMAVSEHKLYWPLGYPPPDVPKCGFD
3D structure
PDB7brk Structural insight into hormone-recognition and transmembrane signaling by the atrial natriuretic peptide receptor
ChainA
Resolution2.85 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.2: guanylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D62 Y88 R95 G113 F165 V168 E169 M173 H185 D62 Y88 R95 G113 F165 V168 E169 M173 H185
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:7brk, PDBe:7brk, PDBj:7brk
PDBsum7brk
PubMed
UniProtP18910|ANPRA_RAT Atrial natriuretic peptide receptor 1 (Gene Name=Npr1)

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