Structure of PDB 7bqv Chain A

Receptor sequence
>7bqvA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
CTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASN
LNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGL
TRSALLPTI
3D structure
PDB7bqv Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N351 H353 Y355 H357 I371 R373 V388 H397 W400 N34 H36 Y38 H40 I54 R56 V71 H80 W83
BS02 F4U A N351 P352 H378 W380 W386 F402 N34 P35 H61 W63 W69 F85 MOAD: Kd=2.28uM
BS03 ZN A C323 C326 C391 C394 C6 C9 C74 C77
External links
PDB RCSB:7bqv, PDBe:7bqv, PDBj:7bqv
PDBsum7bqv
PubMed32929090
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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