Structure of PDB 7bqu Chain A

Receptor sequence
>7bquA (length=109) Species: 9606 (Homo sapiens) [Search protein sequence]
CTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKASN
LNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGL
TRSALLPTI
3D structure
PDB7bqu Structural bases of IMiD selectivity that emerges by 5-hydroxythalidomide.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N351 H353 Y355 H357 I371 V388 A395 H397 N34 H36 Y38 H40 I54 V71 A78 H80
BS02 EF2 A N351 P352 H378 W380 W386 F402 N34 P35 H61 W63 W69 F85 MOAD: Kd=4uM
BindingDB: Ki=22700nM,IC50=29900nM
BS03 ZN A C323 C326 C391 C394 C6 C9 C74 C77
External links
PDB RCSB:7bqu, PDBe:7bqu, PDBj:7bqu
PDBsum7bqu
PubMed32929090
UniProtQ96SW2|CRBN_HUMAN Protein cereblon (Gene Name=CRBN)

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