Structure of PDB 7bq4 Chain A

Receptor sequence
>7bq4A (length=260) Species: 9606 (Homo sapiens) [Search protein sequence]
ADLKSLAKRIYEAYLKNFNMNKVKARVILSGPPFVIHDMETLCMAEKTLV
AKLVANNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTL
LKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPK
FDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVL
RLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHP
LLQEIYRDMY
3D structure
PDB7bq4 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.62 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T288 K292 L302 V306 L309 K310 L459 E462 T80 K84 L94 V98 L101 K102 L251 E254
BS02 EPA A A250 I272 C275 C276 S280 Y314 V332 M355 H440 Y464 A45 I64 C67 C68 S72 Y106 V124 M147 H232 Y256 BindingDB: IC50=1100nM
BS03 GOL A K222 R226 S323 M325 N366 K22 R26 S115 M117 N158
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bq4, PDBe:7bq4, PDBj:7bq4
PDBsum7bq4
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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