Structure of PDB 7bq3 Chain A

Receptor sequence
>7bq3A (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGPPFVIHDMETLCMAEKTLVA
KNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGV
YEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAM
KFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQ
SNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEI
YRDMY
3D structure
PDB7bq3 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.98 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T288 K292 L302 Q305 V306 K310 P458 L459 E462 R465 D466 T75 K79 L89 Q92 V93 K97 P245 L246 E249 R252 D253
BS02 2VN A F273 C276 Q277 T279 S280 Y314 V332 I339 I354 H440 Y464 F60 C63 Q64 T66 S67 Y101 V119 I126 I141 H227 Y251 BindingDB: EC50=200nM,Kd=1.000000nM,IC50=0.46nM,Ki=0.054100nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bq3, PDBe:7bq3, PDBj:7bq3
PDBsum7bq3
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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