Structure of PDB 7bq0 Chain A

Receptor sequence
>7bq0A (length=270) Species: 9606 (Homo sapiens) [Search protein sequence]
MTADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLC
MAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFA
NLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLR
KPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIE
KMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIK
KTESDAALHPLLQEIYRDMY
3D structure
PDB7bq0 PPAR alpha Ligand-Binding Domain Structures with Endogenous Fatty Acids and Fibrates.
ChainA
Resolution1.771 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K292 L302 N303 Q305 V306 K310 E462 R465 D466 K94 L104 N105 Q107 V108 K112 E264 R267 D268
BS02 F5A A F273 C276 Q277 S280 Y314 I354 H440 V444 I447 K448 A454 A455 L456 Y464 F75 C78 Q79 S82 Y116 I156 H242 V246 I249 K250 A256 A257 L258 Y266 BindingDB: EC50=30000nM,IC50=>10000nM,Ki=35000nM
BS03 F5A A L254 K257 C275 T279 A333 Y334 L56 K59 C77 T81 A135 Y136 BindingDB: EC50=30000nM,IC50=>10000nM,Ki=35000nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bq0, PDBe:7bq0, PDBj:7bq0
PDBsum7bq0
PubMed33205029
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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