Structure of PDB 7blv Chain A

Receptor sequence
>7blvA (length=426) Species: 11084 (Tick-borne encephalitis virus) [Search protein sequence]
VVGTGWTSKGQITVLDMHPGSGKTHRVLPELIRQCIDRRLRTLVLAPTRV
VLKEMERALNGKRVRFHSGAIVDVMCHATYVNRRLLPQGRQNWEVAIMDE
AHWTDPHSIAARGHLYTLAKENKCALVLMTATPPGKSEPFPESNGAITSE
ERQIPDGEWRDGFDWITEYEGRTAWFVPSIAKGGAIARTLRQKGKSVICL
NSKTFEKDYSRVRDEKPDFVVTTDISEMGANLDVSRVIDGRTNIKPEEVD
GKVELTGTRRVTTASAAQRRGRVGRQDGRTDEYIYSGQCDDDDSGLVQWK
EAQILLDNITTVATFYGPEQDKMPEVAGHFRLTEEKRKHFRHLLTHCDFT
PWLAWHVAANVSSVTDRSWTWEGPEANAVDEASGDLVTFRSPNGAERTLR
PVWKDARMFKEGRDIKEFVAYASGRR
3D structure
PDB7blv Mechanistic insight into the RNA-stimulated ATPase activity of tick-borne encephalitis virus helicase.
ChainA
Resolution2.099 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G202 S203 G204 K205 T206 H207 N335 R466 G20 S21 G22 K23 T24 H25 N144 R275
BS02 MN A T206 E291 T24 E100
Gene Ontology
Molecular Function
GO:0004386 helicase activity
GO:0005524 ATP binding

View graph for
Molecular Function
External links
PDB RCSB:7blv, PDBe:7blv, PDBj:7blv
PDBsum7blv
PubMed35987382
UniProtP14336|POLG_TBEVW Genome polyprotein

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