Structure of PDB 7bkg Chain A

Receptor sequence
>7bkgA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
HSSGLVPRGSMESGFTSKDTYLSHFNPRDYLEKYYKFGSRHSAESQILKH
LLKNLFKIFCLDGVKGDLLIDIGSGPTIYQLLSACESFKEIVVTDYSDQN
LQELEKWLKAAPAAFDWSPVVTYVCDLEGNRVKGPEKEEKLRQAVKQVLK
CDVTQSQPLGAVPLPPADCVLSTLCLDAACPDLPTYCRALRNLGSLLKPG
GFLVIMDALKSSYYMIGEQKFSSLPLGREAVEAAVKEAGYTIEWFEVISQ
SYSSTMANNEGLFSLVARKLSR
3D structure
PDB7bkg Novel Inhibitors of Nicotinamide- N -Methyltransferase for the Treatment of Metabolic Disorders.
ChainA
Resolution2.326 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.1: nicotinamide N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Y11 Y20 Y25 G63 S64 T67 Y69 D85 Y86 D142 V143 T163 L164 C165 A169 Y21 Y30 Y35 G73 S74 T77 Y79 D95 Y96 D152 V153 T173 L174 C175 A179 BindingDB: IC50=35300nM
BS02 U0Z A Y20 Y24 L164 D167 S201 Y204 S213 Y242 Y30 Y34 L174 D177 S211 Y214 S223 Y252
Gene Ontology
Molecular Function
GO:0008112 nicotinamide N-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0030760 pyridine N-methyltransferase activity
Biological Process
GO:0006769 nicotinamide metabolic process
GO:0009410 response to xenobiotic stimulus
GO:0031100 animal organ regeneration
GO:0032259 methylation
GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway
GO:0045722 positive regulation of gluconeogenesis
GO:0090312 positive regulation of protein deacetylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bkg, PDBe:7bkg, PDBj:7bkg
PDBsum7bkg
PubMed33668468
UniProtP40261|NNMT_HUMAN Nicotinamide N-methyltransferase (Gene Name=NNMT)

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