Structure of PDB 7bk4 Chain A

Receptor sequence
>7bk4A (length=224) Species: 9606 (Homo sapiens) [Search protein sequence]
ANEDMPVERILEAELAVEPKTETYVEANMNDPVTNICQAADKQLFTLVEW
AKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHV
HRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKG
LSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKC
LEHLFFFKLIGDTPIDTFLMEMLE
3D structure
PDB7bk4 Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K284 L294 V298 R302 F450 E453 K52 L62 V66 R70 F218 E221
BS02 LG2 A I268 A272 L309 F313 R316 A327 C432 L436 I36 A40 L77 F81 R84 A95 C200 L204 BindingDB: IC50=8nM,Ki=13nM,EC50=40nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bk4, PDBe:7bk4, PDBj:7bk4
PDBsum7bk4
PubMed33647291
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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