Structure of PDB 7bj3 Chain A

Receptor sequence
>7bj3A (length=936) Species: 1314 (Streptococcus pyogenes) [Search protein sequence]
TSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKT
KARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTH
VSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAI
RDAVNLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGND
SSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTD
DHQAKEMPVLSTNRFEPNKAYDYAYANRGMKEDDFKDVKGKIALIERGDI
DFKDKIANAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLL
KDNSKKTITFNATPKVLPTASDTKLSRFSSWGLTADGNIKPDIAAPGQDI
LSSVANNKYAKLSGTAMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAK
KVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSK
VHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALY
ETSWQKITIPANSSKQVTVPIDASRFSKDLLAQMKNGYFLEGFVRFKQDP
KKEELMSIPYIGFRGDFGNLSALEKPIYDSKDGSSYYHEANSDAKDQLDG
DGLQFYALKNNFTALTTESNPWTIIKAVKEGVENIEDIESSEITETIFAG
TFAKQDDDSHYYIHRHANGKPYAAISPNGDGNRDYVQFQGTFLRNAKNLV
AEVLDKEGNVVWTSEVTEQVVKNYNNDLASTLGSTRFEKTRWDGKDKDGK
VVVNGTYTYRVRYTPISSGAKEQHTDFDVIVDNTTPEVATSATFSTEDRR
LTLASKPKTSQPIYRERIAYTYMDEDLPTTEYISPNEDGTFTLPEEAETM
EGGTVPLKMSDFTYVVEDMAGNITYTPVTKLLEGHS
3D structure
PDB7bj3 Enzyme kinetic and binding studies identify determinants of specificity for the immunomodulatory enzyme ScpA, a C5a inactivating bacterial protease.
ChainA
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.21.110: C5a peptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A S822 N824 D826 N828 D830 S726 N728 D730 N732 D734
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005618 cell wall
GO:0016020 membrane

View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7bj3, PDBe:7bj3, PDBj:7bj3
PDBsum7bj3
PubMed33897974
UniProtP58099|C5AP_STRP1 C5a peptidase (Gene Name=scpA)

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