Structure of PDB 7bj0 Chain A

Receptor sequence
>7bj0A (length=93) Species: 9606 (Homo sapiens) [Search protein sequence]
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMAEVLFYLGQYIMTKRL
YDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB7bj0 Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein-Protein Interaction.
ChainA
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TVH A L54 F55 G58 Q59 I61 M62 Y67 L38 F39 G42 Q43 I45 M46 Y51 BindingDB: IC50=1260nM
BS02 TVH A F91 H96 Y100 F75 H80 Y84 BindingDB: IC50=1260nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7bj0, PDBe:7bj0, PDBj:7bj0
PDBsum7bj0
PubMed33761253
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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