Structure of PDB 7bi9 Chain A

Receptor sequence

>7bi9A (length=821) Species: 10090 (Mus musculus)

QNDEVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNMASVKVSIEI
EGLQLPVTFTCDVSSTVEIIIMQALCWVHDDLNQVDVGSYILKVCGQEEV
LQNNHCLGSHEHIQNCRKWDTEIKLQLLTLSAMCQNLARTAEDDEAPVDL
RNIKEAWTATEQLQFTVYAAHGISSNWVSNYEKYYLICSLSHNGKDLFKP
IQSKKVGTYKNAAYLIKWDELIIFPIQISQLPLESVLHLTLFGVLNQGPE
ALGKVSLTLFDFKRFLTCGTKLAYLWTSERIVLQVDFPSPAFDIIYTSPQ
IDRNIIKLETLESDIKGKLLDIIHRDSSFGLSKEDKVFLWENRYYCLKHP
NCLPKILASAPNWKWANLAKTYSLLHQWPPLCPLAALELLDAKFADQEVR
SLAVSWMEAISDDELADLLPQFVQALKYEIYLNSSLVRFLLSRALGNIQI
AHSLYWLLKDALHDTHFGSRYEHVLGALLSVGGKGLREELSKQMKLVQLL
GGVAEKVRQASGSTRQVVLQKSMERVQSFFLRNKCRLPLKPSLVAKELNI
KSCSFFSSNAMPLKVTMVNADPLGEEINVMFKVGEDLRQDMLALQMIKIM
DKIWLKEGLDLRMVIFRCLSTGRDRGMVELVPASDTLRKIQVEYGVTGSF
KDKPLAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGICDRHNDNI
MLRSTGHMFHIDFGKFLGHAAPFVLTSDMAYVINGGEKPTIRFQLFVDLC
CQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLKYVRDALQPQTTDAE
ATIFFTRLIESSLGSIATKFN

3D structure

• PDB: 7bi9 Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
• Chain: A
• Resolution: 2.65 Å

Enzymatic activity

• Enzyme Commision number: 2.7.1.137: phosphatidylinositol 3-kinase.
  2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
  2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	090	A	K756 D764 F790 E803 V805 S808 M875 I885 D886	K582 D590 F616 E629 V631 S634 M701 I711 D712

Gene Ontology

Molecular Function

• GO:0016301 kinase activity
• GO:0016303 1-phosphatidylinositol-3-kinase activity

Biological Process

• GO:0046854 phosphatidylinositol phosphate biosynthetic process

External links

• PDB: RCSB:7bi9, PDBe:7bi9, PDBj:7bi9
• PDBsum: 7bi9
• PubMed: 35256802
• UniProt: Q61194|P3C2A_MOUSE Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Gene Name=Pik3c2a)