Structure of PDB 7bi2 Chain A

Receptor sequence
>7bi2A (length=1021) Species: 10090 (Mus musculus) [Search protein sequence]
QNDEVAAFCQSIMKLKTKFPYTDHCTNPGYLLSPVTVQRNASVKVSIEIE
GLQLPVTFTCDVSSTVEIIIMQALCWVDVGSYILKVCGQEEVLQNNHCLG
SHEHIQNCRKWDTEIKLQLLTLSAMCQNLARTAEDDEAPVDLRHPVEELL
DSYHYQVELALQTENQHRAVDQVIKAVRKICSALDGVETPSVTEAVKKLK
RAVNLPPENPVQVSMDHLTTAIYDLLRLHANSSNIKEAWTATEQLQFTVY
AAHGISSNWVSYEKYYLICSLSHNGKDLFKPIQSKKVGTYKNFFYLIKWD
ELIIFPIQISQLPLESVLHLTLFALGKVSLTLFDFKRFLTCGTKLLYLWT
SIVLQVDFPSPAFDIIYTSPQIDRNIITLESDIKGKLLDIIHRDSSFGLS
KEDKVFLWENRYYCLKHPNCLPKILASAPNWKWANLAKTYSLLHQWPPLC
PLAALELLDAKFADQEVRSLAVSWMEAISDDELADLLPQFVQALKYEIYL
NSSLVRFLLSRALGNIQIAHSLYWLLKDALHDTHFGSRYEHVLGALLSVG
GKGLREELSKQMKLVQLLGGVAEKVRQASGSTRQVVLQKSMERVQSFFLR
NKCRLPLKPSLVAKELNIKSCSFFSSNAMPLKVTMVNADPLGEEINVMFK
VGEDLRQDMLALQMIKIMDKIWLKEGLDLRMVIFRCLSTGRDRGMVELVP
ASDTLRKIQVELAEWLRKYNPSEEEYEKASENFIYSCAGCCVATYVLGIC
DRHNDNIMLRSTGHMFHIDFGKFLGHAQMFGSFRAPFVLTSDMAYVINGG
EKPTIRFQLFVDLCCQAYNLIRKQTNLFLNLLSLMIPSGLPELTSIQDLK
YVRDALQPQTTDAEATIFFTRLIESSLATKFNFFIHNLAQLRFSLSFSPK
TYSFRQDGRIKEVSVFTYHKKYNPDKHYIYVVRILREGHLEPSFVFRTFD
EFQELHNKLSIIFPLWKLPGFPNGRTHIKDVAAKRKIELNSYLQSLMNAS
TDVAECDLVCTFFHPLLRDEK
3D structure
PDB7bi2 Structural basis of phosphatidylinositol 3-kinase C2 alpha function.
ChainA
Resolution3.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.137: phosphatidylinositol 3-kinase.
2.7.1.153: phosphatidylinositol-4,5-bisphosphate 3-kinase.
2.7.1.154: phosphatidylinositol-4-phosphate 3-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 17G A F730 S732 P736 K756 L804 V805 S808 M875 I885 F624 S626 P630 K650 L698 V699 S702 M758 I768
Gene Ontology
Molecular Function
GO:0016301 kinase activity
GO:0016303 1-phosphatidylinositol-3-kinase activity
GO:0035091 phosphatidylinositol binding
Biological Process
GO:0046854 phosphatidylinositol phosphate biosynthetic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7bi2, PDBe:7bi2, PDBj:7bi2
PDBsum7bi2
PubMed35256802
UniProtQ61194|P3C2A_MOUSE Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha (Gene Name=Pik3c2a)

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