Structure of PDB 7bhp Chain A

Receptor sequence
>7bhpA (length=322) Species: 9606 (Homo sapiens) [Search protein sequence]
QTIAEDLVVTKYKMGGDIANRVLRSLVEASSSGVSVLSLCEKGDAMIMEE
TGKIFKKEMKKGIAFPTSISVNNCVCHFSPLDYILKEGDLVKIDLGVHVD
GFIANVAHTFVVQVTGRKADVIKAAHLCAEAALRLVKPGNQNTQVTEAWN
KVAHSFNCTPIHQLKQHVIKTIIQNPTDQQKKDHEKAEFEVHEVYAVLVS
SGEKDAGQRTTIYKRDPSKQYGLKMKTSRAFFSEVERRFDAMPFTLRAFD
EKKARMGVVECAKHELLQPFNVLYEKGEFVAQFKFTVLLMPNGPMRITSG
PFEPDLYKSMEVQDAELKALLQ
3D structure
PDB7bhp Dynamic association of human Ebp1 with the ribosome.
ChainA
Resolution3.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D109 N120 H188 K320
Catalytic site (residue number reindexed from 1) D94 N105 H162 K284
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 rna A K211 Q254 Y255 G256 L257 K258 K260 R263 A264 S267 R271 L301 K182 Q220 Y221 G222 L223 K224 K226 R229 A230 S233 R237 L266
BS02 rna A K22 K62 K65 K66 K13 K53 K56 K57
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006364 rRNA processing
GO:0006417 regulation of translation
GO:0043066 negative regulation of apoptotic process
GO:0045597 positive regulation of cell differentiation
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0035578 azurophil granule lumen
GO:0070062 extracellular exosome
GO:1990904 ribonucleoprotein complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7bhp, PDBe:7bhp, PDBj:7bhp
PDBsum7bhp
PubMed33479117
UniProtQ9UQ80|PA2G4_HUMAN Proliferation-associated protein 2G4 (Gene Name=PA2G4)

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