Structure of PDB 7b9z Chain A

Receptor sequence
>7b9zA (length=128) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEIAHLLIKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKGE
3D structure
PDB7b9z Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors.
ChainA
Resolution1.44 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T58 A Y57 D68 R73 F77 Q85 V86 W90 Y113 S118 K121 I122 F130 Y45 D56 R61 F65 Q73 V74 W78 Y101 S106 K109 I110 F118
BS02 IS8 A N63 T127 N51 T115
BS03 IS8 A G114 S115 G102 S103
BS04 IS8 A V37 V40 V25 V28
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:7b9z, PDBe:7b9z, PDBj:7b9z
PDBsum7b9z
PubMed33666419
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

[Back to BioLiP]