Structure of PDB 7b9o Chain A

Receptor sequence
>7b9oA (length=209) Species: 9606 (Homo sapiens) [Search protein sequence]
DMPVERILEAELAVEDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQ
VILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFD
RVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVY
ASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPI
DTFLMEMLE
3D structure
PDB7b9o Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A D263 V265 S339 A340 K431 F438 F439 D444 T445 D16 V18 S92 A93 K184 F191 F192 D197 T198
BS02 T72 A I268 Q275 W305 I310 F313 R316 L326 A327 F346 C432 H435 L436 I21 Q28 W58 I63 F66 R69 L79 A80 F99 C185 H188 L189
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:7b9o, PDBe:7b9o, PDBj:7b9o
PDBsum7b9o
PubMed33793232
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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