Structure of PDB 7b9l Chain A

Receptor sequence
>7b9lA (length=299) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA
FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE
KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMRSYMSPERLQGTH
YSVQSDIWSMGLSLVEMAVGRYPIMAIFELLDYIVNEPPPKLPSGVFSLE
FQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGLN
3D structure
PDB7b9l Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
ChainA
Resolution1.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 N195 D208 D217
Catalytic site (residue number reindexed from 1) D158 K160 N163 D176 D185
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A G75 A76 G77 V82 A95 K97 M143 M146 S150 Q153 D190 K192 S194 N195 L197 D208 G43 A44 G45 V50 A63 K65 M111 M114 S118 Q121 D158 K160 S162 N163 L165 D176
BS02 T4N A K97 I99 V127 I141 M143 D190 D208 F209 M219 K65 I67 V95 I109 M111 D158 D176 F177 M187
BS03 MG A N195 D208 N163 D176
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7b9l, PDBe:7b9l, PDBj:7b9l
PDBsum7b9l
PubMed33603979
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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