Structure of PDB 7b9i Chain A

Receptor sequence
>7b9iA (length=352) Species: 9606 (Homo sapiens) [Search protein sequence]
DLRLHLLLNTSVTCNDGSPAGYYLKESRGSRRWLLFLEGGWYCFNRENCD
SRYDTMRRLMSSRDWRTRTGTGILSSQPEENPYWWNANMVFIPYCSSDVW
SGASSKSEKNEYAFMGALIIQEVVRELLGRGLSGAKVLLLAGSSAGGTGV
LLNVDRVAEQLEKLGYPAIQVRGLADSGWFLDNKQYRHTDCVDTITCAPT
EAIRRGIRYWNGVVPERCRRQFQEGEEWNCFFGYKVYPTLRSPVFVVQWL
FDEAQLTVDNVHLTVQEGLRLYIQNLGRELRHTLKDVPASFAPACLSHEI
IIRSHWTDVQVKGTSLPRALHCWDRSLHPLKGCPVHLVDSCPWPHCNPSC
PT
3D structure
PDB7b9i Structural Analysis and Development of Notum Fragment Screening Hits.
ChainA
Resolution1.34 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.1.98: [Wnt protein] O-palmitoleoyl-L-serine hydrolase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T3T A G126 G127 W128 S232 A233 F268 H389 G39 G40 W41 S144 A145 F180 H298
BS02 T3T A D103 Y140 R150 K194 E199 Y200 D16 Y53 R63 K106 E111 Y112
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:7b9i, PDBe:7b9i, PDBj:7b9i
PDBsum7b9i
PubMed35731924
UniProtQ6P988|NOTUM_HUMAN Palmitoleoyl-protein carboxylesterase NOTUM (Gene Name=NOTUM)

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