Structure of PDB 7b9h Chain A

Receptor sequence
>7b9hA (length=332) Species: 9606 (Homo sapiens) [Search protein sequence]
PRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQER
DLLKTFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTP
ALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVL
ENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNL
LADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLY
RQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHP
LWETWADLVHPDAQDILDTLEDNREWYQSTIP
3D structure
PDB7b9h Design, synthesis, biological evaluation and structural characterization of novel GEBR library PDE4D inhibitors.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.53: 3',5'-cyclic-AMP phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H164 H200 D201 D318 H85 H121 D122 D239
BS02 MG A D301 D305 D222 D226
BS03 T3K A H160 M273 D318 N321 I336 M337 F340 M357 Q369 F372 H81 M194 D239 N242 I257 M258 F261 M278 Q290 F293
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:7b9h, PDBe:7b9h, PDBj:7b9h
PDBsum7b9h
PubMed34171658
UniProtQ08499|PDE4D_HUMAN 3',5'-cyclic-AMP phosphodiesterase 4D (Gene Name=PDE4D)

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