Structure of PDB 7b94 Chain A

Receptor sequence
>7b94A (length=301) Species: 9606 (Homo sapiens) [Search protein sequence]
LYFQLEELELDEQQRKRLEAFLTQKQKVGELKDDDFEKISELGAGNGGVV
FKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHECNSPYIVGFYGA
FYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYLRE
KHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMGTRSYMSPERLQG
THYSVQSDIWSMGLSLVEMAVGRYPIMAIFELLDYIVNEPPPKLPSGVFS
LEFQDFVNKCLIKNPAERADLKQLMVHAFIKRSDAEEVDFAGWLCSTIGL
N
3D structure
PDB7b94 Fragment-Based Discovery of Novel Allosteric MEK1 Binders.
ChainA
Resolution2.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D190 K192 N195 D208 D217 T226
Catalytic site (residue number reindexed from 1) D158 K160 N163 D176 D185 T189
Enzyme Commision number 2.7.12.2: mitogen-activated protein kinase kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ANP A L74 G75 A76 G77 V82 A95 K97 M143 M146 S150 Q153 D190 K192 S194 N195 L197 D208 L42 G43 A44 G45 V50 A63 K65 M111 M114 S118 Q121 D158 K160 S162 N163 L165 D176
BS02 MG A N195 D208 N163 D176
BS03 T3W A L118 I141 D208 F209 L215 L86 I109 D176 F177 L183
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7b94, PDBe:7b94, PDBj:7b94
PDBsum7b94
PubMed33603979
UniProtQ02750|MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 (Gene Name=MAP2K1)

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