Structure of PDB 7b88 Chain A

Receptor sequence
>7b88A (length=212) Species: 9606 (Homo sapiens) [Search protein sequence]
MDMPVERILEAELAVEPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPL
DDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGA
IFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALRE
KVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGD
TPIDTFLMEMLE
3D structure
PDB7b88 Oxaprozin Analogues as Selective RXR Agonists with Superior Properties and Pharmacokinetics.
ChainA
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V280 E281 K284 L294 V298 R302 F450 E453 V36 E37 K40 L50 V54 R58 F206 E209
BS02 T2K A I268 A272 Q275 W305 N306 F313 R316 C432 L436 I24 A28 Q31 W61 N62 F69 R72 C188 L192
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003707 nuclear steroid receptor activity
GO:0008270 zinc ion binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b88, PDBe:7b88, PDBj:7b88
PDBsum7b88
PubMed33793232
UniProtP19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)

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