Structure of PDB 7b67 Chain A

Receptor sequence
>7b67A (length=154) Species: 9606 (Homo sapiens) [Search protein sequence]
GVGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEECA
QRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSEPK
NVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVGYK
GNHL
3D structure
PDB7b67 Crystal structures of NUDT15 variants enabled by a potent inhibitor reveal the structural basis for thiopurine sensitivity.
ChainA
Resolution1.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.9: nucleotide diphosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SYW A G17 V18 G19 V40 L47 G50 H51 E90 N91 Y92 Y94 T96 F137 G139 L140 G5 V6 G7 V28 L35 G38 H39 E78 N79 Y80 Y82 T84 F125 G127 L128
BS02 MG A E65 E69 E53 E57
External links
PDB RCSB:7b67, PDBe:7b67, PDBj:7b67
PDBsum7b67
PubMed33753169
UniProtQ9NV35|NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 (Gene Name=NUDT15)

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