Structure of PDB 7b5c Chain A

Receptor sequence
>7b5cA (length=718) Species: 10090 (Mus musculus) [Search protein sequence]
MDYHEDDKRFRREELCREAEFLKLKMPTKKVYHISETRGLLKTINSVLQK
ITDPIQPKVAEHRPQTTKRLSYPFSREKQHLFDLTDRDSFFDSKTRSTIV
YEILKRTTCGITSLLANGVYSAAYPLHDGDYEGDNVEFNDRKLLYEEWAS
YGVFYKYQPIDLVRKYFGEKVGLYFAWLGAYTQMLIPASIVGVIVFLYGC
ATVDENIPSMEMCDQRYNITMCPLCDKTCSYWKMSSACATARASHLFDNP
ATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAE
YEARVLEKSPAYFTNLVSIIFMIAVTFAIVLGVIIYRISTAAALAMNSSP
SVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEE
RLTFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPG
GCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKFIRYLKRKQRYEVDFN
LEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKF
VTELRRPVAIRAKDIGIWYNILRGVGKLAVIINAFVISFTSDFIPRLVYL
YMYSQNGTMHGFVNHTLSSFNVSDFQNGTAPNDPLDLGYEVQICRYKDYR
EPPWSEHKYDISKDFWAVLAARLAFVIVFQNLVMFMSDFVDWVIPDIPKD
ISQQIHKEKVLMVELFMR
3D structure
PDB7b5c Gating the pore of the calcium-activated chloride channel TMEM16A.
ChainA
Resolution3.7 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E654 E702 E705 E734 E476 E510 E513 E542
BS02 CA A N650 N651 N730 E734 N472 N473 N538 E542
Gene Ontology
Molecular Function
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005247 voltage-gated chloride channel activity
GO:0005254 chloride channel activity
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006821 chloride transport
GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway
GO:0034220 monoatomic ion transmembrane transport
GO:0034605 cellular response to heat
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042391 regulation of membrane potential
GO:0050965 detection of temperature stimulus involved in sensory perception of pain
GO:0050966 detection of mechanical stimulus involved in sensory perception of pain
GO:0051649 establishment of localization in cell
GO:0060438 trachea development
GO:0070254 mucus secretion
GO:0106091 glial cell projection elongation
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0016324 apical plasma membrane
GO:0034707 chloride channel complex
GO:0042734 presynaptic membrane
GO:0042995 cell projection
GO:0045202 synapse
GO:0098793 presynapse
GO:0098978 glutamatergic synapse

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b5c, PDBe:7b5c, PDBj:7b5c
PDBsum7b5c
PubMed33542223
UniProtQ8BHY3|ANO1_MOUSE Anoctamin-1 (Gene Name=Ano1)

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