Structure of PDB 7b4e Chain A

Receptor sequence
>7b4eA (length=190) Species: 9606 (Homo sapiens) [Search protein sequence]
SSSVPSQKTYQGSYGFRLGFVTCTYSPALNKMFCQLAKTCPVQLWVDSTP
PPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDGLAPPQHLIRVEGNLRV
EYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILT
IITLEDSSGNLLGRNSFEVRVCACPGRDWRTEEENLRKKG
3D structure
PDB7b4e Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
ChainA
Resolution1.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C176 H179 C238 C242 C75 H78 C135 C139
BS02 QN8 A F113 C124 P142 F20 C23 P41
BS03 QN8 A S227 D228 C229 S124 D125 C126
BS04 QN8 A A276 C277 A173 C174
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7b4e, PDBe:7b4e, PDBj:7b4e
PDBsum7b4e
PubMed34862374
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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