Structure of PDB 7b46 Chain A

Receptor sequence
>7b46A (length=192) Species: 9606 (Homo sapiens) [Search protein sequence]
SVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL
WVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERSDGLAPPQHLIRVE
GNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNR
RPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLR
3D structure
PDB7b46 Structural basis of reactivation of oncogenic p53 mutants by a small molecule: methylene quinuclidinone (MQ).
ChainA
Resolution2.02 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A S241 R273 C275 A276 R280 S143 R175 C177 A178 R182
BS02 ZN A C176 H179 C238 C242 C81 H84 C140 C144
BS03 QN8 A K101 Y103 K6 Y8
BS04 QN8 A S227 C229 S129 C131
BS05 QN8 A K120 S121 A276 C277 K25 S26 A178 C179
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006915 apoptotic process
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:7b46, PDBe:7b46, PDBj:7b46
PDBsum7b46
PubMed34862374
UniProtP04637|P53_HUMAN Cellular tumor antigen p53 (Gene Name=TP53)

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