Structure of PDB 7b40 Chain A

Receptor sequence
>7b40A (length=279) Species: 9606 (Homo sapiens) [Search protein sequence]
LSALNPELVQAVQHVVIGPSSLIVHFNEVIGRGHFGCVYHGTLLDNDGKK
IHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVLSLLGICLGSPLVVL
PYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKFVHRDLAA
RNCMLDEKFTVKVADFGLARDMYDKEYYPVKWMALESLQTQKFTTKSDVW
SFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVML
KCWHPKAEMRPSFSELVSRISAIFSTFIG
3D structure
PDB7b40 Structural Basis for Targeting the Folded P-Loop Conformation of c-MET.
ChainA
Resolution1.76 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D1204 R1208 N1209 D1222
Catalytic site (residue number reindexed from 1) D147 R151 N152 D165
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SWN A I1084 V1092 A1108 K1110 L1157 Y1159 M1160 G1163 M1211 A1226 M1229 I30 V38 A54 K56 L100 Y102 M103 G106 M154 A169 M172
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7b40, PDBe:7b40, PDBj:7b40
PDBsum7b40
PubMed33488978
UniProtP08581|MET_HUMAN Hepatocyte growth factor receptor (Gene Name=MET)

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