Structure of PDB 7b36 Chain A

Receptor sequence
>7b36A (length=268) Species: 9606 (Homo sapiens) [Search protein sequence]
ADPEELFTKLERIGKSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQ
QEITVLSQCDSSYVTKYYGSYLKGSKLWIIMEYLGGGSALDLLRAGPFDE
FQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAGT
PFWMAPEVIQQSAYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLIP
KNNPPTLVGDFTKSFKEFIDACLNKDPSFRPTAKELLKHKFIVKNSKKTS
YLTELIDRFKRWKAEGHS
3D structure
PDB7b36 Structure-Based Design of Selective Salt-Inducible Kinase Inhibitors.
ChainA
Resolution2.10681 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D144 K146 A148 N149 D162 T182
Catalytic site (residue number reindexed from 1) D126 K128 A130 N131 D144 T150
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 59T A V38 A51 K53 E70 L74 M99 L102 A148 L151 D162 V20 A33 K35 E52 L56 M81 L84 A130 L133 D144 BindingDB: IC50=20nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7b36, PDBe:7b36, PDBj:7b36
PDBsum7b36
PubMed34086472
UniProtQ9P289|STK26_HUMAN Serine/threonine-protein kinase 26 (Gene Name=STK26)

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