Structure of PDB 7b05 Chain A

Receptor sequence
>7b05A (length=645) Species: 7955 (Danio rerio) [Search protein sequence]
LSTQEKSYLSAVEKGDYASVKLALEEAEIYFKININCIDPLGRTALLIAI
ENENLEIIELLLSFNVYVGDALLHAIRKEVVGAVELLLNHQFSDFTPDIT
PIILAAHTNNYEIIKMLVQKGVSVPQPHEVVDSLRHSRSRLNIYKALASP
SLIALSSEDPFLTAFQLSWELQELSKVENEFKAEYEELSHQCKHFAKDLL
DQTRSSRELELILNFRNELARLKLAIKYRQKEFVAQPNCQQLLASRWYDE
RHWAGKLITCVFIGLMFPLLSLCYLVAPKSRYGLFIRKPFIKFICHTASY
LTFLFLLLLASQHIVSNNPDRQGPKPTTVEWMILPWVLGFIWTEIKQMWD
GGFQDYIHDWWNLMDFVMNSLYLATISLKIVAYVKYSGCKPRDTWEMWHP
TLVAEAVFAIANIFSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIY
CLVLLAFANGLNQLYFYYENSEGMTCKGIRCERQNNAFSTLFETLQSLFW
SIFGLISLYVTNVKADHKFTEFVGATMFGTYNVISLVVLLNMLIAMMNNS
YQHIADHADIEWKFARTKLWMSYFEEGGTLPPPFNIAENVRLNHQYQEVL
RNLVKRYVAAMIRDAKTEEGLTEENFKELKQDISSFRYEVIGMMK
3D structure
PDB7b05 Structural basis of TRPC4 regulation by calmodulin and pharmacological agents.
ChainA
Resolution3.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SJQ A Y373 F413 D438 M441 N442 S488 R491 L495 Y300 F340 D365 M368 N369 S415 R418 L422
BS02 CA A E417 Q420 N435 E344 Q347 N362
BS03 44E A Q569 F572 Q496 F499
BS04 44E A F595 A598 F522 A525
Gene Ontology
Molecular Function
GO:0005216 monoatomic ion channel activity
GO:0005261 monoatomic cation channel activity
GO:0005262 calcium channel activity
GO:0015279 store-operated calcium channel activity
GO:0070679 inositol 1,4,5 trisphosphate binding
Biological Process
GO:0006811 monoatomic ion transport
GO:0006812 monoatomic cation transport
GO:0051480 regulation of cytosolic calcium ion concentration
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034703 cation channel complex

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Biological Process
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Cellular Component
External links
PDB RCSB:7b05, PDBe:7b05, PDBj:7b05
PDBsum7b05
PubMed33236980
UniProtU3N7D8

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