Structure of PDB 7az4 Chain A

Receptor sequence
>7az4A (length=248) Species: 5665 (Leishmania mexicana) [Search protein sequence]
KPQPIAAANWKCNGTTASIEKLVQVFNEHTISHDVQCVVAPTFVHIPLVQ
AKLRNPKYVISAQNAIAKSGAFTGEVSMPILKDIGVHWVILGHSERRTYY
GETDEIVAQKVSEACKQGFMVIACIGETLQQREANQTAKVVLSQTSAIAA
KLTKDAWNQVVLAYEPVWAIGTGKVATPEQAQEVHLLLRKWVSENIGTDV
AAKLRILYGGSVNAANAATLYAKPDINGFLVGGASLKPEFRDIIDATR
3D structure
PDB7az4 Neutron structures of Leishmania mexicana triosephosphate isomerase in complex with reaction-intermediate mimics shed light on the proton-shuttling steps.
ChainA
Resolution1.15 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.3.1.1: triose-phosphate isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PGA A K13 H95 E167 I172 G173 G212 S213 G234 G235 K11 H93 E165 I170 G171 G210 S211 G232 G233
Gene Ontology
Molecular Function
GO:0004807 triose-phosphate isomerase activity
GO:0016853 isomerase activity
Biological Process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0019563 glycerol catabolic process
GO:0046166 glyceraldehyde-3-phosphate biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0020015 glycosome

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External links
PDB RCSB:7az4, PDBe:7az4, PDBj:7az4
PDBsum7az4
PubMed34258011
UniProtP48499|TPIS_LEIME Triosephosphate isomerase

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