Structure of PDB 7ayr Chain A

Receptor sequence
>7ayrA (length=802) Species: 9606 (Homo sapiens) [Search protein sequence]
LEPFYVERYSWSQLKKLLADTRKAKAPHDFMFVKRNDPDGPHSDRIYYLA
MSNRENTLFYSEIPKTINRAAVLMLSWKPLLDLFQIASYDYHQGSGTFLF
QAGSGIYHVKDGGPQGFTQQPLRPNLVETSCPNIRMDPKLCPADPDWIAF
IHSNDIWISNIVTREERRLTYVHNELANMEEDARSAGVATFVLQEEFDRY
SGYWWCPKAETTPSGGKILRILYEENDESEVEIIHVTDSFRYPKTGTANP
KVTFKMSEIMIDAEGRIIDVIDKELIQPFEILFEGVEYIARAGWTPEGKY
AWSILLDRSQTRLQIVLISPELFIPVEDDVMERQRLIESVPDSVTPLIIY
EETTDIWINIHDIFHVFPQSHEEEIEFIFASECKTGFRHLYKITSILKES
KYKRSSGGLPAPSDFKCPIKEEIAITSGEWEVLGRHGSNIQVDEVRRLVY
FEGTKDSPLEHHLYVVSYVNPGEVTRLTDRGYSHSCCISQHCDFFISKYS
NQKNPHCVSLYKLSSPEDDPTCKTKEFWATILDSAGPLPDYTPPEIFSFE
STTGFTLYGMLYKPHDLQPGKKYPTVLFIYGGPQVQLVNNRFKGVKYFRL
NTLASLGYVVVVIDNRGSCHRGLKFEGAFKYKMGQIEIDDQVEGLQYLAS
RYDFIDLDRVGIHGWSYGGYLSLMALMQRSDIFRVAIAGAPVTLWIFYDT
GYTERYMGHPDQNEQGYYLGSVAMQAEKFPSEPNRLLLLHGFLDENVHFA
HTSILLSFLVRAGKPYDLQIYPQVPESGEHYELHLLHYLQENLGSRIAAL
KV
3D structure
PDB7ayr Chemoproteomics-Enabled Identification of 4-Oxo-beta-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9.
ChainA
Resolution2.69 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y669 S755 Y756 D833
Catalytic site (residue number reindexed from 1) Y580 S666 Y667 D744
Enzyme Commision number 3.4.14.5: dipeptidyl-peptidase IV.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMO A Y669 S755 Y756 Y787 Y791 Y580 S666 Y667 Y698 Y702
BS02 S9W A R688 W754 S755 D833 N835 L880 R599 W665 S666 D744 N746 L785
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0005515 protein binding
GO:0008236 serine-type peptidase activity
GO:0008239 dipeptidyl-peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006915 apoptotic process
GO:0006955 immune response
GO:0043069 negative regulation of programmed cell death
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7ayr, PDBe:7ayr, PDBj:7ayr
PDBsum7ayr
PubMed36089535
UniProtQ6V1X1|DPP8_HUMAN Dipeptidyl peptidase 8 (Gene Name=DPP8)

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