Structure of PDB 7aym Chain A

Receptor sequence
>7aymA (length=275) Species: 9606 (Homo sapiens) [Search protein sequence]
GPRVDFPRKLLTFKEKLGEGFGEVHLCEVEGMSANQPVLVAVKMLRADAN
KNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQF
LSRHQPTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI
KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFG
VTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSV
YELMLSCWRRDTKNRPSFQEIHRLL
3D structure
PDB7aym Structure of DDR2 Kinase domain in complex with IBZ3
ChainA
Resolution2.12 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D719 R723 N724 D737
Catalytic site (residue number reindexed from 1) D136 R140 N141 D154
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4VD A A606 K608 E625 M629 T654 Y656 M657 L726 A736 D737 A41 K43 E60 M64 T89 Y91 M92 L143 A153 D154
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:7aym, PDBe:7aym, PDBj:7aym
PDBsum7aym
PubMed
UniProtQ08345|DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 (Gene Name=DDR1);
Q16832|DDR2_HUMAN Discoidin domain-containing receptor 2 (Gene Name=DDR2)

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