Structure of PDB 7axs Chain A

Receptor sequence

>7axsA (length=313) Species: 9606 (Homo sapiens) [Search protein sequence]

SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKI
WGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC
LKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHS
DPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK
FSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGG
KWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAAL
ENDKTIKLWKSDC

3D structure

PDB

7axs Bistable Photoswitch Allows in Vivo Control of Hematopoiesis.

Chain

Resolution

1.88 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	A47 S49 A65 I90 S91 D107 F133 F149 K259 Y260 C261 F263 I305	A26 S28 A44 I69 S70 D86 F112 F128 K238 Y239 C240 F242 I284

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0035064	methylated histone binding
GO:0042393	histone binding
GO:0042800	histone H3K4 methyltransferase activity

	Biological Process
GO:0000122	negative regulation of transcription by RNA polymerase II
GO:0001501	skeletal system development
GO:0006094	gluconeogenesis
GO:0006325	chromatin organization
GO:0006355	regulation of DNA-templated transcription
GO:0006357	regulation of transcription by RNA polymerase II
GO:0045722	positive regulation of gluconeogenesis
GO:0045815	transcription initiation-coupled chromatin remodeling
GO:0045893	positive regulation of DNA-templated transcription
GO:0045995	regulation of embryonic development
GO:0051302	regulation of cell division
GO:0051726	regulation of cell cycle
GO:0090043	regulation of tubulin deacetylation

	Cellular Component
GO:0000123	histone acetyltransferase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0035097	histone methyltransferase complex
GO:0044545	NSL complex
GO:0044665	MLL1/2 complex
GO:0044666	MLL3/4 complex
GO:0048188	Set1C/COMPASS complex
GO:0071339	MLL1 complex
GO:0072686	mitotic spindle
GO:0140672	ATAC complex

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:7axs, PDBe:7axs, PDBj:7axs
PDBsum	7axs
PubMed	35106373
UniProt	P61964\|WDR5_HUMAN WD repeat-containing protein 5 (Gene Name=WDR5)

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