Structure of PDB 7axl Chain A

Receptor sequence
>7axlA (length=277) Species: 9606 (Homo sapiens) [Search protein sequence]
VQGLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVAAKWSQVRKDLC
SLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGIISF
AKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYC
LEDTAGGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVL
QHRVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQH
TQRLLRIQDIHPFATPLMQELFGITGS
3D structure
PDB7axl Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
ChainA
Resolution2.5 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 EST A D205 M243 S247 F251 H407 R410 L411 D48 M86 S90 F94 H250 R253 L254
BS02 S65 A L209 M243 M246 S247 Q285 F288 W299 M323 L52 M86 M89 S90 Q128 F131 W142 M166
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:7axl, PDBe:7axl, PDBj:7axl
PDBsum7axl
PubMed33361153
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

[Back to BioLiP]