Structure of PDB 7axj Chain A

Receptor sequence
>7axjA (length=276) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGVSREEAAKWSQVRKD
LCSLKVSLQLRGEDGSVWNYKPPADSGGKEIFSLLPHMADMSTYMFKGII
SFAKVISYFRDLPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLS
YCLEGFQQLLLEPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQH
RVVDQLQEQFAITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQ
RLLRIQDIHPFATPLMQELFGITGSL
3D structure
PDB7axj Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
ChainA
Resolution2.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CL6 A L209 M243 F281 Q285 F288 W299 Y306 M323 L54 M88 F126 Q130 F133 W144 Y151 M164
BS02 EST A D205 L206 S247 F251 H407 R410 L411 D50 L51 S92 F96 H248 R251 L252
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7axj, PDBe:7axj, PDBj:7axj
PDBsum7axj
PubMed33361153
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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