Structure of PDB 7axc Chain A

Receptor sequence
>7axcA (length=264) Species: 9606 (Homo sapiens) [Search protein sequence]
GLTEEQRMMIRELMDAQMKTFDTTFSHFKNFRLPGAAKWSQVRKDLCKVS
LQLRGEDGSVWNYKPPADEIFSLLPHMADMSTYMFKGIISFAKVISYFRD
LPIEDQISLLKGAAFELCQLRFNTVFNAETGTWECGRLSYCLEDFQQLLL
EPMLKFHYMLKKLQLHEEEYVLMQAISLFSPDRPGVLQHRVVDQLQEQFA
ITLKSYIECNRPQPAHRFLFLKIMAMLTELRSINAQHTQRLLRIQDIHPF
ATPLMQELFGITGS
3D structure
PDB7axc Mechanistic insights into the synergistic activation of the RXR-PXR heterodimer by endocrine disruptor mixtures.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 27H A M243 Q285 F288 W299 Y306 E321 M323 H407 M77 Q119 F122 W133 Y140 E151 M153 H237
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:7axc, PDBe:7axc, PDBj:7axc
PDBsum7axc
PubMed33361153
UniProtO75469|NR1I2_HUMAN Nuclear receptor subfamily 1 group I member 2 (Gene Name=NR1I2)

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