Structure of PDB 7awf Chain A

Receptor sequence
>7awfA (length=127) Species: 9606 (Homo sapiens) [Search protein sequence]
GAPATVTEQGEDITSKKDRGVLKIVKRVGNGEETPMIGDKVYVHYKGKLS
NGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEIAHLLIKPEYA
YGSAGSLPKIPSNATLFFEIELLDFKG
3D structure
PDB7awf Macrocyclic FKBP51 Ligands Define a Transient Binding Mode with Enhanced Selectivity.
ChainA
Resolution1.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.2.1.8: peptidylprolyl isomerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S8N A Y57 G59 K60 F77 G84 Q85 V86 I87 W90 Y113 F130 Y45 G47 K48 F65 G72 Q73 V74 I75 W78 Y101 F118
Gene Ontology
Molecular Function
GO:0003755 peptidyl-prolyl cis-trans isomerase activity

View graph for
Molecular Function
External links
PDB RCSB:7awf, PDBe:7awf, PDBj:7awf
PDBsum7awf
PubMed33843131
UniProtQ13451|FKBP5_HUMAN Peptidyl-prolyl cis-trans isomerase FKBP5 (Gene Name=FKBP5)

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