Structure of PDB 7awd Chain A

Receptor sequence
>7awdA (length=272) Species: 9606 (Homo sapiens) [Search protein sequence]
SMQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIY
DMNSLMMGEDKIKFPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIP
GFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLK
SLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVK
PIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQ
VIKKTETDMSLHPLLQEIYKDL
3D structure
PDB7awd Endogenous vitamin E metabolites mediate allosteric PPAR gamma activation with unprecedented co-regulatory interactions.
ChainA
Resolution1.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NQD A P227 L228 Q286 R288 S289 E295 I326 M329 F363 H449 Y473 P27 L28 Q82 R84 S85 E91 I122 M125 F159 H245 Y269
BS02 NQD A E259 I262 Q273 R280 I281 C285 R288 L340 I341 S342 E59 I62 Q69 R76 I77 C81 R84 L136 I137 S138
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:7awd, PDBe:7awd, PDBj:7awd
PDBsum7awd
PubMed33989565
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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