Structure of PDB 7auw Chain A

Receptor sequence
>7auwA (length=532) Species: 9606 (Homo sapiens) [Search protein sequence]
NSIIGEKYRWPHTIPYVLEDSLEMNAKGVILNAFERYRLKTCIDFKPWAG
ETNYISVFKGSGCWSSVGNRRVGKQELSIGANCDRIATVQHEFLHALGFW
HEQSRSDRDDYVRIMWDRILSGREHNFNTYSDDISDSLNVPYDYTSVMHY
SKTAFQNGTEPTIVTRISDFEDVIGQRMDFSDSDLLKLNQLYNCSSSLSF
MDSCSFELENVCGMIQSSGDNADWQRVSQVPRGPESDHSNMGQCQGSGFF
MHFDSSSVNVGATAVLESRTLYPKRGFQCLQFYLYNSGSESDQLNIYIRE
YSADNVDGNLTLVEEIKEIPTGSWQLYHVTLKVTKKFRVVFEGRKGSGAS
LGGLSIDDINLSETRCPHHIWHIRNFTQFIGSPNGTLYSPPFYSSKGYAF
QIYLNLAHVTNAGIYFHLISGANDDQLQWPCPWQQATMTLLDQNPDIRQR
MSNQRSITTDPFMTTDNGNYFWDRPSKVGTVALFSNGTQFRRGGGYGTSA
FITHERLKSRDFIKGDDVYILLTVEDISHLNS
3D structure
PDB7auw The crystal structure of a 250-kDa heterotetrameric particle explains inhibition of sheddase meprin beta by endogenous fetuin-B.
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.63: meprin B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A Y454 N484 Y393 N423
BS02 MAN A S456 K457 S395 K396
BS03 MAN A N484 Q487 N423 Q426
BS04 ZN A H152 H156 H162 H91 H95 H101
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7auw, PDBe:7auw, PDBj:7auw
PDBsum7auw
PubMed33782129
UniProtQ16820|MEP1B_HUMAN Meprin A subunit beta (Gene Name=MEP1B)

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