Structure of PDB 7aun Chain A

Receptor sequence
>7aunA (length=163) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
RENQVYSPVTGARLVAGCICLTPDKKQVLMITSSAHKKRWIVPKGGVEKD
EPNYETTAQRETWEEAGCIGKIVANLGTVEDMRPPDIKQFENSRKDSEVA
KHPPRTEFHFYELEIENLLDKFPECHKRHRKLYSYTEAKQNLIDAKRPEL
LEALNRSAIIKDD
3D structure
PDB7aun Multiple substrate recognition by yeast diadenosine and diphosphoinositol polyphosphate phosphohydrolase through phosphate clamping.
ChainA
Resolution1.95 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.1.10: endopolyphosphatase.
3.6.1.52: diphosphoinositol-polyphosphate diphosphatase.
3.6.1.60: diadenosine hexaphosphate hydrolase (AMP-forming).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 4WZ A R32 S52 S53 H55 I60 K63 G64 E80 E84 R171 R13 S33 S34 H36 I41 K44 G45 E61 E65 R147
BS02 MG A K63 E84 K44 E65
Gene Ontology
Molecular Function
GO:0000298 endopolyphosphatase activity
GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity
GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity
GO:0046872 metal ion binding
GO:1990174 phosphodiesterase decapping endonuclease activity
Biological Process
GO:0006798 polyphosphate catabolic process
GO:0015961 diadenosine polyphosphate catabolic process
GO:0071543 diphosphoinositol polyphosphate metabolic process
GO:1901907 diadenosine pentaphosphate catabolic process
GO:1901909 diadenosine hexaphosphate catabolic process
GO:1901911 adenosine 5'-(hexahydrogen pentaphosphate) catabolic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7aun, PDBe:7aun, PDBj:7aun
PDBsum7aun
PubMed33893105
UniProtQ99321|DDP1_YEAST Diphosphoinositol polyphosphate phosphohydrolase DDP1 (Gene Name=DDP1)

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