Structure of PDB 7auc Chain A

Receptor sequence
>7aucA (length=493) Species: 9606 (Homo sapiens) [Search protein sequence]
LKHERFQSLSFPHTKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFIL
MPTGGGKSLCYQLPACVSPGVTVVISPLRSLIVDQVQKLTSLDIPATYLT
GSEATNIYLQLSKKDPIIKLLYVTPEKICASNRLISTLENLYERKLLARF
VIDEAHMLRQKFPSVPVMALTATANPRVQKDILTQLKILRPQVFSMSFNR
HNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQ
RDGLAALAYHAGLSDSARDEVQQKWINQDGCQVICATIAFGMGIDKPDVR
FVIHASLPKSVEGYYQESGRAGRDGEISHCLLFYTYHDVTRLKRLIMMEK
DGNHHTRETHFNNLYSMVHYCENITECRRIQLLAYFGENGFNPDFCKKHP
DVSCDNCCKKVSQREEMVKKCLGELTEVCKSLGKVFGVHYFNIFNTVTLK
KLAESLSSDPEVLLQIDGVTEDKLEKYGAEVISVLQKYSEWTS
3D structure
PDB7auc Uncovering an allosteric mode of action for a selective inhibitor of human Bloom syndrome protein.
ChainA
Resolution1.53 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 5.6.2.4: DNA 3'-5' helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A L665 N667 R669 Q672 T691 G692 G694 K695 S696 R982 L27 N29 R31 Q34 T53 G54 G56 K57 S58 R323
BS02 MG A D684 L848 D46 L189
BS03 ZN A C1036 C1055 C1063 C1066 C377 C396 C404 C407
BS04 CA A E1047 F1050 E388 F391
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004386 helicase activity
GO:0005524 ATP binding
Biological Process
GO:0006310 DNA recombination
GO:0044237 cellular metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:7auc, PDBe:7auc, PDBj:7auc
PDBsum7auc
PubMed33647232
UniProtP54132|BLM_HUMAN RecQ-like DNA helicase BLM (Gene Name=BLM)

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