Structure of PDB 7aua Chain A

Receptor sequence
>7auaA (length=686) Species: 9606 (Homo sapiens) [Search protein sequence]
GCRLHNCFDYSRCPLTSGFPVYVYDSDQFVFGSYLDPLVKQAFQATARAN
VYVTENADIACLYVILVGEMQEPVVLRPAELEKQLYSLPHWRTDGHNHVI
INLSRKSDTQNLLYNVSTGRAMVAQSTFYTVQYRPGFDLVVSPLVHAMSE
PNFMEIPPQVPVKRKYLFTFQGEKDYDDRIIATLKAVQDSKLDQVLVEFT
CKNQPKPSLPTEWALCGEREDRLELLKLSTFALIITPGDPRLVISSGCAT
RLFEALEVGAVPVVLGEQVQLPYQDMLQWNEAALVVPKPRVTEVHFLLRS
LSDSDLLAMRRQGRFLWETYFSTADSIFNTVLAMIRTRIQIPAAPIREEA
AAEIPHRSPPYASPRYLRNFTLTVTDFYRSWNCAPGPFHLFPHTPFDPVL
PSEAKFLGSGTGFRPIGGGAGGSGKEFQAALGGNVPREQFTVVMLTYERE
EVLMNSLERLNGLPYLNKVVVVWNSPKLPSEDLLWPDIGVPIMVVRTEKN
SLNNRFLPWNEIETEAILSIDDDAHLRHDEIMFGFRVWREARDRIVGFPG
RYHAWDIPHQSWLYNSNYSCELSMVLTGAAFFHKYYAYLYSYVMPQAIRD
MVDEYINCEDIAMNFLVSHITRKPPIKVTSRWTFRDDSHFHERHKCINFF
VKVYGYMPLLYTQFRVDSVLFKTRLPHDKTKCFKFI
3D structure
PDB7aua The structure of EXTL3 helps to explain the different roles of bi-domain exostosins in heparan sulfate synthesis.
ChainA
Resolution2.93 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.4.1.223: glucuronosyl-galactosyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MAN A H782 S784 H877 H559 S561 H644
BS02 UDP A L668 T669 Y670 R672 D745 D746 L445 T446 Y447 R449 D522 D523
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0001888 glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
GO:0005515 protein binding
GO:0008375 acetylglucosaminyltransferase activity
GO:0016500 protein-hormone receptor activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
Biological Process
GO:0006486 protein glycosylation
GO:0010838 positive regulation of keratinocyte proliferation
GO:0015012 heparan sulfate proteoglycan biosynthetic process
GO:0030307 positive regulation of cell growth
GO:0045617 negative regulation of keratinocyte differentiation
GO:0050728 negative regulation of inflammatory response
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0106015 negative regulation of inflammatory response to wounding
GO:1900016 negative regulation of cytokine production involved in inflammatory response
GO:2000972 positive regulation of detection of glucose
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7aua, PDBe:7aua, PDBj:7aua
PDBsum7aua
PubMed35676258
UniProtO43909|EXTL3_HUMAN Exostosin-like 3 (Gene Name=EXTL3)

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