Structure of PDB 7au9 Chain A

Receptor sequence
>7au9A (length=489) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence]
ARSVRHIAIPAHRGLITDRNGEPLAVSTPVTTLWANPKELMTAKERWPQL
AAALGQDTKLFADRIEQNAEREFIYLVRGLTPEQGEGVIALKVPGVYSIE
EFRRFYPAGEVVAHAVGFTDVDDRGREGIELAFDEWLAGVPGKRQVLKDR
QVTKNAKPGKTLALSIDLRLQYLAHRELRNALLENGAKAGSLVIMDVKTG
EILAMTNQPTYNPNNRRNLQPAAMRNRAMIDVFEPGSTVKPFSMSAALAS
GRWKPSDIVDVYPGTLQIGRYTIRDVSRNSRQLDLTGILIKSSNVGISKI
AFDIGAESIYSVMQQVGLGQDTGLGFPGERVGNLPNHRKWPKAETATLAY
GYGLSVTAIQLAHAYAALANDGKSVPLSMTRVDRVPDGVQVISPEVASTV
QGMLQQVVEAQGGVFRAQVPGYHAAGKSGTARKENAYRSLFAGFAPATDP
RIAMVVVIDEPSFGGLVSAPVFSKVMAGALRLMNVPPDN
3D structure
PDB7au9 High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes.
ChainA
Resolution2.137 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.16.4: serine-type D-Ala-D-Ala carboxypeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S1E A S294 S349 N351 Y407 Y409 K484 T487 S237 S292 N294 Y350 Y352 K427 T430
Gene Ontology
Molecular Function
GO:0004180 carboxypeptidase activity
GO:0008658 penicillin binding
GO:0008955 peptidoglycan glycosyltransferase activity
GO:0009002 serine-type D-Ala-D-Ala carboxypeptidase activity
Biological Process
GO:0000917 division septum assembly
GO:0006508 proteolysis
GO:0008360 regulation of cell shape
GO:0009252 peptidoglycan biosynthetic process
GO:0043093 FtsZ-dependent cytokinesis
GO:0051301 cell division
GO:0071555 cell wall organization
Cellular Component
GO:0005886 plasma membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7au9, PDBe:7au9, PDBj:7au9
PDBsum7au9
PubMed34337941
UniProtG3XD46|FTSI_PSEAE Peptidoglycan D,D-transpeptidase FtsI (Gene Name=ftsI)

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