Structure of PDB 7arz Chain A

Receptor sequence

>7arzA (length=361) Species: 3218 (Physcomitrium patens)

AFSYSSAAGGESKKILGVFFAAHEYAKNPEFLGCVENALGIREWLESKGH
KYVVTSDKDGPDSELDKELADAHILITTPFHPAYMTKERLAKAKNLELLV
TAGVGSDHIDLHAAAEKGLTVSEVTGSNVTSVAEDEVLRILVLVRNFAPG
WKQVSEGGWNVAAVVHHAYDLIDRTVGTVGGGRIGQELMKRLKGFGLKEM
LYYDRNSLGAEREKELGCKRETDLDTMLSKCDVVVVNTPLTDQTRGLFNK
ERIAKMKKGAYLVNNARGAIADTEAVKEACESGHLGGYGGDVWNAQPAGK
DHPWRYMPNHAMTPHISGTTLDAQKRFAAGTKDMIDRWLKHEAFPEQNYI
VREGKLASQYL

3D structure

• PDB: 7arz Ternary complex of NAD-dependent formate dehydrogenase from Physcomitrium patens
• Chain: A
• Resolution: 2.15 Å

Enzymatic activity

• Enzyme Commision number: 1.17.1.9: formate dehydrogenase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	NAD	A	V145 N169 V173 G223 R224 I225 D245 R246 T279 P280 Q284 N306 A307 R308 D332 H356 S358 G359 Q400	V104 N128 V132 G182 R183 I184 D204 R205 T238 P239 Q243 N265 A266 R267 D291 H315 S317 G318 Q359
BS02	AZI	A	P120 F121 G144 V145 R308 H356	P79 F80 G103 V104 R267 H315
BS03	AZI	A	T118 L140 V141 T142	T77 L99 V100 T101

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0008863 formate dehydrogenase (NAD+) activity
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0051287 NAD binding

Biological Process

• GO:0042183 formate catabolic process

Cellular Component

• GO:0005739 mitochondrion

External links

• PDB: RCSB:7arz, PDBe:7arz, PDBj:7arz
• PDBsum: 7arz
• UniProt: A9SQZ2