Structure of PDB 7ara Chain A

Receptor sequence
>7araA (length=139) Species: 12130 (rhinovirus A2) [Search protein sequence]
GPSDMYVHVGNLIYRNLHLFNSEMHESILVSYSSDLIIYRTNTVGDDYIP
SCDCTQATYYCKHKNRYFPITVTSHDWYEIQESEYYPKHIQYNLLIGEGP
CEPGDCGGKLLCKHGVIGIVTAGGDNHVAFIDLRHFHCA
3D structure
PDB7ara Defining substrate selection by rhinoviral 2A proteinase through its crystal structure with the inhibitor zVAM.fmk.
ChainA
Resolution2.243 Å
3D
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Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
3.4.22.28: picornain 3C.
3.4.22.29: picornain 2A.
3.6.1.15: nucleoside-triphosphate phosphatase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 S7N A H18 Y78 Q81 S83 Y85 G104 C106 T121 A122 G123 G124 H127 H18 Y78 Q81 S83 Y85 G104 C106 T121 A122 G123 G124 H127
BS02 ZN A C54 H114 C54 H114
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016032 viral process

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Molecular Function
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Biological Process
External links
PDB RCSB:7ara, PDBe:7ara, PDBj:7ara
PDBsum7ara
PubMed34315103
UniProtP04936|POLG_HRV2 Genome polyprotein

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