Structure of PDB 7aqm Chain A

Receptor sequence
>7aqmA (length=328) Species: 7897 (Latimeria chalumnae) [Search protein sequence]
PMVSLAQVRGALCGALLGDCMGAEFEGSDAVELPDVLEFVRLLEKEKKAG
TLFYTDDTAMTRAVIQSLIAKPDFDEVDMAKRFAEEYKKEPTRGYGAGVV
QVFKKLLSPKYSDVFQPAREQFDGKGSYGNGGAMRVASIALAYPNIQDVI
KFARRSAQLTHASPLGYNGAILQALAVHFALQGELKRDTFLEQLIGEMER
IEKLPFCSRLKKIKEFLASSNVPKADIVDELGHGIAALESVPTAIYSFLH
CMESDPDIPDLYNNLQRTIIYSISLGGDTDTIATMAGAIAGAYYGMDQVT
PSWKRSCEAIVETEESAVKLYELYCKQL
3D structure
PDB7aqm Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.2.1.143: poly(ADP-ribose) glycohydrolase.
3.2.2.-
3.5.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A T62 D63 D64 D305 T55 D56 D57 D280
BS02 MG A E33 D303 D305 E26 D278 D280
BS03 RVK A E33 D63 G101 G105 V106 F129 S134 Y135 G136 N137 G138 H168 D303 T306 E26 D56 G94 G98 V99 F122 S127 Y128 G129 N130 G131 H161 D278 T281
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004649 poly(ADP-ribose) glycohydrolase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006281 DNA repair
GO:0060546 negative regulation of necroptotic process
GO:0140290 peptidyl-serine ADP-deribosylation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Cellular Component
External links
PDB RCSB:7aqm, PDBe:7aqm, PDBj:7aqm
PDBsum7aqm
PubMed34321462
UniProtH3BCW1|ADPRS_LATCH ADP-ribosylhydrolase ARH3 (Gene Name=adprs)

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