Structure of PDB 7aqb Chain A

Receptor sequence
>7aqbA (length=294) Species: 9606 (Homo sapiens) [Search protein sequence]
GFDLGSRYMDLKPLGNGLVFSAVDNDCDKRVAIKKIVLTDPQSVKHALRE
IKIIRRLDHDNIVKVFEILGPSGSQLTDLTELNSVYIVQEYMETDLANVL
EQGPLLEEHARLFMYQLLRGLKYIHSANVLHRDLKPANLFINTEDLVLKI
GDFGLARIMDHLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEML
TGKTLFAGAHELEQMQLILESIPVVHEEDRQELLSVIPVYIRNDMTEPHK
PLTQLLPGISREAVDFLEQILTFSPMDRLTAEEALSHPYMSIYS
3D structure
PDB7aqb Crystal Structure and Inhibitor Identifications Reveal Targeting Opportunity for the Atypical MAPK Kinase ERK3.
ChainA
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D152 K154 N157 D171 T194
Catalytic site (residue number reindexed from 1) D133 K135 N138 D152 T168
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG A N157 D171 N138 D152
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:7aqb, PDBe:7aqb, PDBj:7aqb
PDBsum7aqb
PubMed33114754
UniProtQ16659|MK06_HUMAN Mitogen-activated protein kinase 6 (Gene Name=MAPK6)

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