Structure of PDB 7apo Chain A

Receptor sequence
>7apoA (length=233) Species: 9606 (Homo sapiens) [Search protein sequence]
EVGELIEKVRKAHQETFPALCQLGKYTTNNSSEQRVSLDIDLWDKFSELS
TKCIIKTVEFAKQLPGFTTLTIADQITLLKAACLDILILRICTRYTPEQD
TMTFSDGLTLNRTQMHNAGFGPLTDLVFAFANQLLPLEMDDAETGLLSAI
CLICGDRQDLEQPDRVDMLQEPLLEALKVYVRKRRPSRPHMFPKMLMKIT
DLRSISAKGAERVITLKMEIPGSMPPLIQEMLE
3D structure
PDB7apo Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR).
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A T233 I237 K244 I254 I258 K262 P408 L409 M413 T51 I55 K62 I72 I76 K80 P226 L227 M231
BS02 EQN A F228 L231 S232 L266 L269 F286 S287 F302 F46 L49 S50 L84 L87 F104 S105 F120 BindingDB: EC50=4nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0048384 retinoic acid receptor signaling pathway
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:7apo, PDBe:7apo, PDBj:7apo
PDBsum7apo
PubMed33647291
UniProtP10276|RARA_HUMAN Retinoic acid receptor alpha (Gene Name=RARA)

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