Structure of PDB 7aop Chain A

Receptor sequence

>7aopA (length=156) Species: 9606 (Homo sapiens)

GRRPGVGVGVVVTSCKHPRCVLLGKRKGSVGAGSFQLPGGHLEFGETWEE
CAQRETWEEAALHLKNVHFASVVNSFIEKENYHYVTILMKGEVDVTHDSE
PKNVEPEKNESWEWVPWEELPPLDQLFWGLRCLKEQGYDPFKEDLNHLVG
YKGNHL

3D structure

• PDB: 7aop NUDT15-mediated hydrolysis limits the efficacy of anti-HCMV drug ganciclovir.
• Chain: A
• Resolution: 2.35 Å

Enzymatic activity

• Enzyme Commision number: 3.6.1.9: nucleotide diphosphatase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RTW	A	L45 G47 H49 S83 Y90 Y92 T94 F135 W136 G137 L138	L37 G39 H41 S75 Y82 Y84 T86 F127 W128 G129 L130
BS02	MG	A	G47 E63 E67	G39 E55 E59

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity
• GO:0016787 hydrolase activity
• GO:0035539 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
• GO:0044715 8-oxo-dGDP phosphatase activity
• GO:0046872 metal ion binding
• GO:0047429 nucleoside triphosphate diphosphatase activity

Biological Process

• GO:0000278 mitotic cell cycle
• GO:0000302 response to reactive oxygen species
• GO:0006195 purine nucleotide catabolic process
• GO:0006203 dGTP catabolic process
• GO:0009217 purine deoxyribonucleoside triphosphate catabolic process
• GO:0042178 xenobiotic catabolic process
• GO:0042262 DNA protection
• GO:0055086 nucleobase-containing small molecule metabolic process
• GO:0061136 regulation of proteasomal protein catabolic process
• GO:1901292 nucleoside phosphate catabolic process

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:7aop, PDBe:7aop, PDBj:7aop
• PDBsum: 7aop
• PubMed: 34192523
• UniProt: Q9NV35|NUD15_HUMAN Nucleotide triphosphate diphosphatase NUDT15 (Gene Name=NUDT15)