Structure of PDB 7amk Chain A

Receptor sequence
>7amkA (length=476) Species: 7955 (Danio rerio) [Search protein sequence]
LYFPQRLYTENIYVGQQQGSPLLQVISMREFPTERPYFFLCSHRDAFTSW
FHIDEASGVLYLNKTLEWSDFSSLRSGSVRSPKDLTLKVGVSSTPPMKVM
CTILPTVEVKLSFINDTAPSCGQVELSTLCFPEKISNPHITENREPGALR
QLRRFTHMSICPNYTISYGVVAGSSVPFAVDDSTSELVVTAQVDREEKEV
YHLDIVCMVRTERNLEEVFRSLHVNIYDEDDNSPYVQGTDTEDVLVEFDR
SEGTVFGTLFVYDRDTTPVYPTNQVQNKLVGTLMTQDSWIKNNFAIEHKF
REEKAIFGNVRGTVHEYKLKLSQNLSVTEQRSFLLGYLVNDTTFPGPEGT
VLLHFNVTVLPVPIRFSQVTYSFTVSQKATTYSQIGKVCVENCQKFKGID
VTYQLEIVDRQITAEAQSCYWAVSLAQNPNDNTGVLYVNDTKVLRRPECQ
ELEYVVIAQEQQNKLQAKTQLTVSFQ
3D structure
PDB7amk A two-site flexible clamp mechanism for RET-GDNF-GFR alpha 1 assembly reveals both conformational adaptation and strict geometric spacing.
ChainA
Resolution2.2 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CA A E164 D216 E218 D253 E142 D194 E196 D231
BS02 CA A E164 E218 D250 E251 D253 D287 E142 E196 D228 E229 D231 D265
BS03 CA A D252 N254 D285 D287 N299 D363 D230 N232 D263 D265 N277 D341
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:7amk, PDBe:7amk, PDBj:7amk
PDBsum7amk
PubMed33484636
UniProtA8E7C6

[Back to BioLiP]