Structure of PDB 7alv Chain A

Receptor sequence

>7alvA (length=472) Species: 9606 (Homo sapiens) [Search protein sequence]

KDYRKKYRKYVRSRFQCIELNKRYTRLRLIKEHSPIKMELLFDPDEPVHT
VVFQGAAGIGKTILARKMMLDWASGTLYQDRFDYLFYIHCREVSLVTQRS
LGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFDEHIGPLCTD
WQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEIL
GFSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTG
LKQQMESGKSLAQTSKTTTAVYVFFLSSLLCAHLWGLCSLAADGIWNQKI
LFEESDLRNHGLQDVSAFLRMNLFQKEVKFYSFIHMTFQEFFAAMYYLLE
ESRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERSYLEKKLSCKISQQI
RLELLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIE
INLSTRMDHMVSSFCIENCHRV

3D structure

PDB

7alv Crystal Structure of NLRP3 NACHT Domain With an Inhibitor Defines Mechanism of Inflammasome Inhibition.

Chain

Resolution

2.835 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

3.6.4.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	RM5	A	A227 A228 R351 I411 T439 F575 R578 L628 Y632	A56 A57 R180 I240 T268 F372 R375 L424 Y428
BS02	ADP	A	Y168 T169 L171 G229 G231 K232 T233 I234 Y381 P412 W416 H522	Y24 T25 L27 G58 G60 K61 T62 I63 Y210 P241 W245 H335

External links

PDB	RCSB:7alv, PDBe:7alv, PDBj:7alv
PDBsum	7alv
PubMed	34687713
UniProt	Q96P20\|NLRP3_HUMAN NACHT, LRR and PYD domains-containing protein 3 (Gene Name=NLRP3)

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